Product & ReviewsAntibodies

CyFlow™ CD148 APC

Product Details

Cat. No.
AJ142881
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Buy Now
Sysmex Europe SE

Receive your quote directly from the manufacturer.

Description

CD148 (HPTP-eta, DEP-1) is a transmembrane protein tyrosin phosphatase containing eight fibronectin type III extracellular domains. This protein is known to inhibit transduction of mitogenic signals in non-hematopoietic cells (fibroblasts, epithelial cells), and signal transduction downstream of T cell receptor, however, it also augments immunoreceptor signaling in B cells and macrophages via dephosphorylating C-terminal tyrosine of Src-family tyrosine kinases. CD148 expression increases after in vitro activation of peripheral blood leukocytes. It can be also used as marker of the most mature human thymocytes, and leukemic cells corresponding to this stadium of thymocyte differentiation. In contrast, in mice the CD148 expression sharply drops through the double positive stage to the single positive thymocytes.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: CD148
  • Clone: MEM-CD148/05
  • Conjugate: APC
  • Isotype: IgG2b

Handling

  • Quantity: 100 tests
  • Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
  • Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

  • Flow Cytometry (FC)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links