CyFlow™ CD222 APC
Product Details
- Cat. No.
- BP264904
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
CD222 (CIMPR; cation-independent mannose 6-phosphate receptor or IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-β, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Non-Human Primate
- Antigen: CD222
- Clone: MEM-238
- Conjugate: APC
- Isotype: IgG1
Handling
- Quantity: 100 tests
- Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
- Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.
Applications
- Flow Cytometry (FC)
- Western Blotting (WB)