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CyFlow™ CD5 PE-Cy7

Sysmex Europe SE
0.0/5.0
|0 Reviews|Write your own Review

Product Details

Cat. No.
AP444245
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Sysmex Europe SE

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Product Overview

CyFlow™ CD5 PE-Cy7

Sysmex Europe SE
0.0/5.0
|0 Reviews

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Sysmex Europe SE

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  • Summary
  • Reviews

Description

CD5 (T1) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: CD5
  • Clone: L17F12
  • Conjugate: PE-Cy7
  • Isotype: IgG2a

Handling

  • Quantity: 100 tests
  • Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
  • Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

  • Flow Cytometry (FC)
  • Immunocytochemistry (ICC)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
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