CyFlow™ CD62P Low Endotoxin

CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human, Non-Human Primate
• Antigen: CD62P
• Clone: AK4
• Conjugate: Low Endotoxin
• Isotype: IgG1

• Quantity: 0.1 mg
• Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
• Buffer: The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

• Flow Cytometry (FC)
• Functional Studies (Func)
• Immunocytochemistry (ICC)
• Immunoprecipitation (IP)
• Western Blotting (WB)