Product & ReviewsAntibodies

CyFlow™ CD62P Low Endotoxin

Product Details

Cat. No.
BR187242
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
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Sysmex Europe SE

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Description

CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human, Non-Human Primate
  • Antigen: CD62P
  • Clone: AK4
  • Conjugate: Low Endotoxin
  • Isotype: IgG1

Handling

  • Quantity: 0.1 mg
  • Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
  • Buffer: The reagent is provided in azide-free phosphate buffered saline (PBS) solution, pH ≈7.4; 0.2 µm filter sterilized. Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Applications

  • Flow Cytometry (FC)
  • Functional Studies (Func)
  • Immunocytochemistry (ICC)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
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