Product & ReviewsAntibodies

CyFlow™ CD79a PE

Product Details

Cat. No.
AX816454
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
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Sysmex Europe SE

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Description

CD79a (Ig α, MB1) forms disulfide-linked heterodimer with CD79b (Ig β, B29). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with λ5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Chicken, Cow, Guinea Pig, Horse (Equine), Human, Mouse, Opossum, Pig (Swine), Rabbit (Lapine), Rat
  • Antigen: CD79a
  • Clone: HM57
  • Conjugate: PE
  • Isotype: IgG1

Handling

  • Quantity: 100 tests
  • Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
  • Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

  • Flow Cytometry (FC)
  • Immunohistochemistry (IHC)
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