Product & ReviewsAntibodies
CyFlow™ FoxP3 Purified
Product Details
- Cat. No.
- BA054642
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
Buy Now
Receive your quote directly from the manufacturer.
Receive your quote directly from the manufacturer.
FoxP3 (Forkhead box protein 3), a highly conserved forkhead/winged-helix transcription factor, plays a crucial role in maintaining immune homeostasis by governing the development and function of regulatory T cells. It is constitutively expressed at high level in CD25+ CD4+ Treg cells and at low level in a CD25- CD4+ Treg cell subset. Defects in gene encoding FoxP3 protein cause the scurfy phenotype in mice, and in human the IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome.