Product & ReviewsAntibodies

CyFlow™ LARGE1 PE

Product Details

Cat. No.
CF600136
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
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Sysmex Europe SE

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Description

LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein α-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of α-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered α-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: LARGE1
  • Clone: LARGE-02
  • Conjugate: PE
  • Isotype: IgG2b

Handling

  • Quantity: 0.1 mg
  • Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
  • Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

Applications

  • Flow Cytometry (FC)
  • Western Blotting (WB)
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