CyFlow™ LARGE1 PE

LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein α-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of α-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered α-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Antigen: LARGE1
• Clone: LARGE-02
• Conjugate: PE
• Isotype: IgG2b

• Quantity: 0.1 mg
• Storage: Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
• Buffer: The reagent is provided in stabilizing phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.1% (w/v) sodium azide.

• Flow Cytometry (FC)
• Western Blotting (WB)