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Delangin (NPBL) plays a structural role in chromatin cohesion, likely by interacting with the cohesin complex. Delangin deficiencies are the cause of Cornelia de Lange syndrome type 1 (CDLS1), which is a heterogeneous developmental disorder associated with malformations affecting multiple systems such as member growth, cognitive retardation, cardiac anomalies. This antibody recognizes the isoform B (short form) of human and mouse delangin in Western blot, immunoprecipitation, immunofluorescent staining and immunohistochemistry.