Product & ReviewsAntibodies

Desmin (10H7) Antibody

Product Details

Cat. No.
252674
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

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Description

Desmin is a class-III intermediate filament found in muscle cells. In adult striated muscle desmin forms a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Defects in desmin are the cause of myopathy myofibrillar desmin-related (MFM-DES), also known as desmin-related myopathy (DRM). DRM is a neuromuscular disorder characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure and by myofibrillar destruction with intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: Purified recombinant fragment of Desmin expressed in E. coli.
  • Clone: 10H7D2
  • Isotype: Mouse IgG1
  • Gene: P17661

Handling

  • Quantity: 0.1 mg
  • Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.

Applications

  • Immunohistochemistry (IHC)
  • Western Blotting (WB)
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