DNMT3A rat antibody (mAb) (Clone 6A4)
Product Details
- Cat. No.
- 61477
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
DNMT3A (DNA (cytosine-5)-methyltransferase 3A) is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Not Species Specific, Human, Mouse
- Clone: 6A4
- Isotype: IgG2a
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunofluorescence (IF)
- Western Blotting (WB)