Product & ReviewsAntibodies
DNMT3L rabbit antibody (pAb), sample
Product Details
- Cat. No.
- 39908
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
DNMT3L (DNA methyltransferase 3-like) is a nuclear protein with similarity to the DNMT family of proteins, but does not function as a DNA methyltransferase. It serves as an essential regulator of DNMT3A and DNMT3B, recruiting them to sites for deposition of de novo DNA methylation. DNMT3L is expressed in the presumptive gametes in mammalian embryos and is required for the establishment of genomic imprinting. DNMT3L binds to chromatin through interactions with the amino terminal tail of histone H3 that is devoid of lysine 4 methylation.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Isotype: IgG
Handling
- Quantity: 10 ul
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Western Blotting (WB)