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HLA class II histocompatibility antigen, DRB1-4 beta chain (DR-4) is a heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. DR-4 binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases.