Product & ReviewsAntibodies
DR3/TRAMP Antibody
Product Details
- Cat. No.
- 250889
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Tumor necrosis factor receptor superfamily member 25 (TRAMP/DR3 or Apoptosis-mediating receptor DR3) is the receptor for TNFSF12/APO3L/TWEAK. TRAMP interacts directly with the adapter TRADD. TRAMP mediates activatio of NFkB and induces apoptosis. TRAMP/DR3 plays a role in regulating lymphocyte homeostasis. TRAMP/DR3 forms homodimers to interact strongly via the death domains with TNFRSF1 and TRADD to activate the apoptosis and NFkB signaling cascades. DR3 is highly expressed in thymocytes and lymphocytes.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N/C-term region of human TRAMP/DR3.
- Isotype: Rabbit Ig
- Gene: Q93038
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)