Ectodysplasin-A Antibody
Product Details
- Cat. No.
- 251518
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Ectodysplasin-A is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 of ectodysplasin-A binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in ectodysplasin-A are the cause of ectodermal dysplasia type 1 (ED1), also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Ectodysplasin-A.
- Isotype: Rabbit Ig
- Gene: Q92838
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)