EGFR Isoform 3
Product Details
- Cat. No.
- 200211
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
Epidermal growth factor receptor (EGFR) is a receptor for EGF and for various members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentation. Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis and cell proliferation. EGFR isoform 3 (sEGFR, p110) is a 77 kDa isoform consisting of the extracellular EGFR domain and a unique, truncated carboxy terminus region without transmembrane domain. EGFR isoform 3 is being investigated as a marker for epithelial ovarian cancer. This antibody is specific for isoform 3, it will not recognized full-length EGFR and EGFR vIII.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encomassing a sequence within the C-term region of human EGFR isoform 3.
- Isotype: Rabbit Ig
- Gene: P00533
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)