Product & ReviewsAntibodies
EIF2AK3 (5G5) Antibody
Product Details
- Cat. No.
- 253074
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3; PERK) is a Ser/Thr protein kinase. It phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and to a rapid reduction of translational initiation and repression of global protein synthesis. PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. Defects in PERK are the cause of Wolcott-Rallison syndrome, an early-onset diabetes mellitus.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of human EIF2AK3 expressed in E. coli.
- Clone: 5G5
- Isotype: Mouse IgG1
- Gene: Q9NZJ5, NP_004827
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)