EP300 (7D8A) Antibody
Product Details
- Cat. No.
- 252813
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
EP300 (E1A binding protein p300) is an adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It is a histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. p300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this protein cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of EP300 expressed in E. coli.
- Clone: 7D8A6
- Isotype: Mouse IgG1
- Gene: Q7Z6C1
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)