ER-alpha (N-term) Antibody
Product Details
- Cat. No.
- 251251
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The estrogen receptor (ER-alpha) is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. ER-alpha can activate the transcriptional activity of TFF1. ER-alpha binds DNA as a homodimer, and can form a heterodimer with ESR2. ER-alpha interacts with FOXC2, MAP1S, SLC30A9, UBE1C and the coactivators NCOA3, NCOA5, NCOA6, and NCOA7. Genetic variations in ER-alpha are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Chicken, Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ER-alpha.
- Isotype: Rabbit Ig
- Gene: P03372
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)