Product & ReviewsAntibodies
ERAB Antibody
Product Details
- Cat. No.
- 250634
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Mouse
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Description
Endoplasmic reticulum-associated beta-amyloid peptide binding protein (ERAB) is an intracellular polypeptide that binds to beta-amyloid-beta, a neurotoxic peptide that has been implicated in the pathogenesis of Alzheimer's disease. ERAB is a hydroxysteroid dehydrogenase enzyme expressed in normal tissues, but overexpressed in neurons affected in Alzheimer's disease. Overexpression of ERAB in cultured cells enhances the neurotoxic effects of beta-amyloid. Defects in ERAB are the cause of neurological abnormalities including mental and psychomotor retardation.
Biological Information
- Clonality: Polyclonal
- Host: Mouse
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ERAB.
- Isotype: Mouse Ig
- Gene: Q99714
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)