EZH2 mouse antibody (mAb) (Clone AC22)
Product Details
- Cat. No.
- 39875
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
EZH2 is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein, and contains a SET domain that catalyzes the methylation of histone H3 at lysine 27. Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and SUZ12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. Deregulation of EZH2 is linked to a variety of cancers.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse
- Clone: AC22
- Isotype: IgG2a
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- Specificity: 4
Applications
- Chromatin Immunoprecipitation (ChIP)
Mixed results
RNA Immunoprecipitation
Mixed results in RNA Immunoprecipitation experiments
Review Date: 17 Mar 2023 | Active Motif