Factor B Antibody
Product Details
- Cat. No.
- 250119
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
The complement factor B is part of the alternate pathway of the complement system. Factor B is cleaved by factor D into two fragments, Ba and Bb, the latter being a serine protease that binds to complement component 3b (C3b) to generate the C3 or C5 convertase. Factor B is involved in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. Among the 15 variants of factor B gene, the variants His-9 and Gln-32 are associated with a reduced risk of age-related macular degeneration (ARMD). This antibody recognizes human complement factor B in indirect and sandwich ELISA.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified human complement factor B protein
- Clone: KT21
- Isotype: mouse IgG2b
- Gene: P00751, NP_001701
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)