Product & ReviewsAntibodies
FasL Antibody
Product Details
- Cat. No.
- 250646
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Fas ligand (FasL or CD95L) is a cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. FasL is involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis has a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells or both. Defects in FasL are the cause of autoimmune lymphoproliferative syndrome 1B (ALPS1B), a childhood syndrome involving hemolytic anemia and thrombocytopenia.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FasL.
- Isotype: Rabbit Ig
- Gene: P48023
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)