Fibrillarin Antibody
Product Details
- Cat. No.
- 253136
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Fibrillarin is a nucleolar protein involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Rat, Yeast
- Antigen: Yeast nuclear preparations.
- Clone: 38F3
- Isotype: Mouse IgG1
- Gene: P15646
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunofluorescence (IF)
- Western Blotting (WB)