Filaggrin Antibody (AE21)

Profilaggrin is a large, insoluble, highly phosphorylated precursor protein containing several tandem copies of a 324 amino acid stretch. Mammalian profilaggrin is a major protein component of keratohyalin granules in the living cells of the epidermis. Keratohyalin granules contribute to the keratin content of dead cornified cells. During terminal differentiation of the epidermis, profilaggrin is proteolytically processed into active filaggrin molecules that promote aggregation and disulfide-bond formation of keratin intermediate filaments. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USALI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

• Clonality: Monoclonal
• Host: Mouse
• Reactivity: Human
• Isotype: IgG1
• Gene: 2312

• Specificity: 2

• Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
• Western Blotting (WB)