Product & ReviewsAntibodies
FXR Antibody
Product Details
- Cat. No.
- 252165
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Bile acid receptor (FXR) is a ligand-activated transcription factor. FXR is a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. FXR represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression via two distinct mechanisms. FXR activates the intestinal bile acid-binding protein (IBABP). FXR activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human FXR.
- Isotype: Rabbit Ig
- Gene: Q96RI1
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)