GABABR2 Antibody
Product Details
- Cat. No.
- 251656
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Gamma-aminobutyric acid type B receptor subunit 2 (GABABR2) is a receptor for GABA. The activity of GABABR2 is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium-channels and modulate inositol phospholipid hydrolysis. GABABR2 plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABABR2 inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABABR2 decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. GABABR2 is not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Dog (Canine), Horse (Equine), Human, Mouse, Rabbit (Lapine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GABABR2.
- Isotype: Rabbit Ig
- Gene: O75899
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)