Product & ReviewsAntibodies

Gap-43 (Ser41) Antibody

Product Details

Cat. No.
252546
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

GAP-43 (Growth associated protein-43, neuromodulin) is a cytoplasmic axonal membrane protein that is involved in the neuronal outgrowth and synaptic plasticity of developing and regenerating neurons . Palmitoylated GAP-43 attaches to the membrane via lipid rafts, while the unmodified form is a component of the centrosome. GAP-43 binds to calmodulin in the absence of Ca++ and functions as a substrate for PKC in the nerve growth factor (NGF) signaling pathway. Gap-43 functions as an adapter protein, binding and interacting with several molecules including PKC, PIP2, actin, calmodulin, spectrin, palmitate, synaptophysin, amyloid, and tau. A lack of GAP-43 or phosphorylation leads to severe neuronal developmental or learning disfunction.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Bovine, Chicken, Dog (Canine), Human, Mouse, Xenopus, Zebrafish
  • Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser41 of rat Gap-43.
  • Isotype: Rabbit Ig
  • Modifications: Phosphospecific Antibody
  • Gene: P07936

Handling

  • Quantity: 0.1 ml
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Western Blotting (WB)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links