Product & ReviewsAntibodies

GAPDH Mouse mAb

Product Details

Cat. No.
AC002
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
ABclonal Technology

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Description

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human, Mouse, Rat

Handling

  • Specificity: 5

Applications

    Average Rating 5.0

    |1Scientists have reviewed this product

    Specificity rating
    Sensitivity rating
    Quality rating
    Write your own review

    Performs very well with low sample input.

     

    Average Rating 5.0

    Application Area:

    Western blot

    High quality and sensitivity with reproducible results. Works at 1:20,000 with LI-COR Odyssey digital fluorescent imaging (IRdye secondaries).

    Review Date: 17 Jun 2021 | ABclonal Technology

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