Product & ReviewsAntibodies

GATA3 (1A10) Antibody

Product Details

Cat. No.
252756
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Abbiotec

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Description

"GATA3 (GATA binding protein 3) is an enhancer-binding protein containing a zinc finger domain. The genes for all 4 subunits of the T-cell antigen receptor (alpha, beta, gamma and delta) are controlled by distinct enhancers and their enhancer-binding proteins. A common TCR regulatory element was identified by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all 4 TCR genes. GATA3 mRNA was demonstrated by Northern blot analysis in T cells but not in B cells, macrophages, or HeLa cell lines. GATA3 is abundantly expressed in the T-lymphocyte lineage and is thought to participate in T-cell receptor gene activation through binding to enhancers. The human gene comprises 6 exons distributed over 17 kb of DNA. Its 2 zinc fingers are encoded by 2 separate exons highly conserved with those of GATA1, but no other structural homologies between the 2 genes could be found. "

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Human
  • Antigen: Purified recombinant fragment of GATA3(aa175-388) expressed in E. coli.
  • Clone: 1A10D1
  • Isotype: Mouse IgG1
  • Gene: P23771

Handling

  • Quantity: 0.1 ml
  • Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.

Applications

  • Western Blotting (WB)
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