Geminin rabbit antibody (pAb)
Product Details
- Cat. No.
- 61135
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Geminin is a crucial cell cycle regulatory protein that controls DNA replication and centrosome function. Geminin inhibits DNA replication by preventing the binding of the MCM complex into the pre-replication complex. Geminin accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition. Geminin functions as a homotetramer and interacts with DNA replication licensing factor CDT1. The interaction between Geminin and CDT1 is crucial to restrict DNA replication to once per cell cycle. Geminin is required for the formation of pluripotent cells in the developing embryo and essential for pluripotency in the embryonic stem cells. In ESCs, Geminin remains during G1 and sustains core pluripotency factors (Oct4, Sox2, and Nanog) by antagonizing the action of the chromatin remodeling protein BRG1.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Isotype: Serum
Handling
- Quantity: 100 ul
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunoprecipitation (IP)
- Western Blotting (WB)