Gliadin Peptide (14D5) Antibody
Product Details
- Cat. No.
- 250437
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin. This antibody reacts strongly with the deamidated peptide but cross-reacts about 5% with the non-deamidated peptide KLQPFPQPQLPYPQPQ
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Plants
- Antigen: Gliadin-related peptide (alpha-gliadin aa58-73, KLQPFPQPELPYPQPQ) coupled to immunogenic carrier protein PPD (tuberculin).
- Clone: 14D5
- Isotype: Mouse IgG2a
- Gene: Q41531
Handling
- Quantity: 0.2 mg
- Storage: Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Applications
- ELISA (ELISA)