GluR2 (Ser880) Antibody
Product Details
- Cat. No.
- 252549
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
The glutamate receptor 2, a homo- or heter0teramer, is an Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The glutamate receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Ser880 has been identified as a PKC phosphorylation site within the C-terminal region of GluR2 and has been shown to differentially regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Chicken, Human, Mouse, Rat, Zebrafish
- Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser880 of rat GluR2-subunit.
- Isotype: Rabbit Ig
- Modifications: Phosphospecific Antibody
- Gene: P19491
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)