GOAT ANTI TRAP2

Goat anti Human TRAP2 antibody recognizes TRAP2, also known as 26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit S2, 26S proteasome subunit p97, protein 55.11 or tumor necrosis factor type 1 receptor-associated protein 2.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. TRAP2 (or PSMD2) encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of TRAP2 (provided by RefSeq, Jul 2013). Goat anti Human TRAP2 antibody detects a band of 100 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

• Clonality: Polyclonal
• Host: Goat
• Reactivity: Human, Mouse, Rat
• Isotype: Polyclonal IgG

• Quantity: 100 µl
• Storage: -20ºC only
• Buffer: TRIS buffered saline, 0.02% Sodium Azide, 0.5% BSA

• Western Blotting (WB)