GPR143 Antibody
Product Details
- Cat. No.
- 252189
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
G-protein coupled receptor 143 (GPR143) is a receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, GPR143 stimulates Ca2+ influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane. This ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. The activity of GPR143 is mediated by G proteins which activate the phosphoinositide signaling pathway. GPR143 also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Defects in GPR143 are the cause of albinism ocular type 1 (OA1), also known as Nettleship-Falls type ocular albinism. This is a form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR143.
- Isotype: Rabbit Ig
- Gene: P51810
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)