Gremlin 1 antibody
Product Details
- Cat. No.
- orb10741
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Immunofluorescence analysis of mouse bone marrow tissue using Gremlin 1 antibody (dilution of primary antibody - 2.5 ug/ml)
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Description
Gremlin-1 (Grem1); an antagonist of bone morphogenetic proteins; is involved in fibrotic tissue formation in kidney and lung. Like BMPs; BMP antagonists contain cystine knots and typically form homo- and heterodimers. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP; this gene may play a role in regulating organogenesis; body patterning; and tissue differentiation. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) .Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Pig (Swine), Rat
- Clone: NULL
- Conjugate: Unconjugated
- Isotype: IgG
- Gene: 26585
Handling
- Quantity: 100 ?g
- Storage: Store at 4°C for up to two weeks. For long term storage; aliquot and store at -20°C; avoid freeze/thaw cycles.
- Buffer: 10 mM PBS; 0.02% sodium azide
Applications
- Immunofluorescence (IF)
- Immunohistochemistry (Paraffin-Embedded Sections) (IHC (P))
- Western Blotting (WB)
