Product & ReviewsAntibodies
GRK5 Antibody
Product Details
- Cat. No.
- 200217
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptores (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. GRK5 is inhibited by calmodulin. Autophosphorylation play a critical role in the regulation of GRK5 kinase activity. GRK5 is overexpressed during heart failure.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Cat (Feline), Chicken, Chimpanzee, Guinea Pig, Human, Monkey, Mouse, Rat, Xenopus
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GRK5.
- Isotype: Rabbit Ig
- Gene: P34947
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)