Product & ReviewsAntibodies

HAMSTER ANTI MOUSE CD152

Product Details

Cat. No.
MCA4636
Type
Primary Antibody
Clonality
Monoclonal
Host
Hamster
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Bio-Rad

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Description

Hamster anti Mouse CD152 antibody, clone 1B8 recognizes mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on naïve T-cells and is induced upon T-cell activation. In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high binding affinity of CD152 make it a potential therapy for autoimmune diseases such as rheumatoid arthritis. Hamster anti Mouse CD152 antibody, clone 1B8 may be used to enhance proliferation and pro-inflammatory cytokines of lymph node cells. It may also be used to enhance tumour immunity.

Biological Information

  • Clonality: Monoclonal
  • Host: Hamster
  • Reactivity: Mouse
  • Isotype: IgG

Handling

  • Quantity: 0.25 mg
  • Storage: +4ºC, -20ºC if preferred
  • Buffer: Phosphate buffered saline, 0.09% Sodium Azide

Applications

  • ELISA (ELISA)
  • Flow Cytometry (FC)
  • Immunofluorescence (IF)
  • Immunoprecipitation (IP)
  • Western Blotting (WB)
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