HCCR-1 Antibody
Product Details
- Cat. No.
- 250682
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Human cervical cancer oncogene (HCCR-1) is a human oncoprotein, and has shown strong tumorigenic features. Its role in tumorogenesis is from a negative regulation of the p53 tumor suppressor gene. HCCR-1 is located in mitochondrial outer membrane, where its function is to retard intrinsic apoptosis experimentally-induced by UVC and staurosporine. Uncontrolled expression of HCCR-1 causes mitochondrial dysfunction, resulting in the progression of tumor formation. HCCR-1 has also been shown to be a regulatory factor that stimulates morphogenesis of epithelia or mesenchyme during neoplastic transformation.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Dog (Canine), Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human HCCR-1.
- Isotype: Rabbit Ig
- Gene: Q8WY22
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)