HDAC3 (3A7B) Antibody
Product Details
- Cat. No.
- 252812
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
HDAC3 (Histone deacetylase 3) is a histone deacetylase protein. Histones play a critical role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of HDAC3(aa224-428) expressed in E. coli.
- Clone: 3A7B5
- Isotype: Mouse IgG1
- Gene: O15379
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Immunohistochemistry (IHC)
- Western Blotting (WB)