Product & ReviewsAntibodies

HIF-1 alpha mouse antibody (mAb) (Clone ESEE122)

Product Details

Cat. No.
61275
Type
Primary Antibody
Clonality
Monoclonal
Host
Mouse
Active Motif

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Description

HIF-1 (hypoxia inducible factor 1, alpha subunit, MOP1, PASD8, bHLHe78, PAS domain-containing protein 8) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.

Biological Information

  • Clonality: Monoclonal
  • Host: Mouse
  • Reactivity: Bovine, Human, Mouse, Rat
  • Clone: ESEE122
  • Isotype: IgG1

Handling

  • Quantity: 100 ug
  • Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Applications

  • Immunohistochemistry (IHC)
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