Product & ReviewsAntibodies
HIF-PH3 Antibody
Product Details
- Cat. No.
- 251184
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
HIF-prolyl hydroxylase 3 (HIF-PH3) catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF-PH3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. HIF-PH3 plays a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. HIF-PH3 promotes cell death through a caspase-dependent mechanism.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Dog (Canine), Human, Mouse, Pig (Swine), Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human HIF-PH3.
- Isotype: Rabbit Ig
- Gene: Q9H6Z9
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)