Histone H2BS14ph mouse antibody (mAb) (Clone MABI 0251)
Product Details
- Cat. No.
- 61011
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Histone H2B is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Histone H1 is a linker histone, present at the interface between the nucleosome core and DNA entry/exit points. Histone H1 is responsible for establishing higher-order chromatin structure. Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins. H2B is phosphorylated at serine 14 in response to DNA damage (dependant upon PI3 kinase kinase activity) and during apoptosis.by the Mst1 kinase.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Not Species Specific, Human
- Clone: MABI 0251
- Isotype: IgG1
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunofluorescence (IF)
- Western Blotting (WB)