Histone H4K16ac rabbit antibody (pAb)
Product Details
- Cat. No.
- 39167
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Histone H4 is one of the core components of the nucleosome, the basic building block of chromatin. Acetylation of histones is linked to a number of specific processes including transcriptional regulation and genomic organization. In yeast, acetylation of histone H3 at lysine 16 is required to maintain the boundaries between euchromatin (open and transcriptionally competent regions of chro¬matin) and heterochromatin (closed and transcriptionally inert). In Drosophila, lysine 16 acetylation is involved in the process of dosage compensation, the coordinate up-regulation of genes on the single male X chromosome that equalizes gene expression with that of genes on the two X chromosomes in females. In humans, the loss of lysine 16 acetylation appears to be a hallmark of specific types of cancer. Acetylation of lysine 16 inhibits the formation of higher order chromatin structure, suggesting that lysine 16 is a central regulator.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Not Species Specific, Drosophila melanogaster, Human, Mouse, Yeast
- Isotype: Serum
Handling
- Quantity: 200 ul
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Chromatin Immunoprecipitation (ChIP)
- Dot Blot (DB)
- Western Blotting (WB)