HLA-DMB Rabbit pAb
Product Details
- Cat. No.
- A8384
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
Western blot - HLA-DMB antibody (A8384)
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Description
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human
