Product & ReviewsAntibodies

HLA DRA Antibody

5.0/5.0

Product Details

Cat. No.: NBP2-45043
Type: Primary Antibody
Clonality: Monoclonal
Host: Mouse

Flow Cytometry: HLA DRA Antibody (169-1B5.2) [NBP2-45043] - A surface stain was performed on human peripheral blood lymphocytes with HLA DRA (169-1B5.2) antibody NBP2-47722APC and a matched isotype control NBP2-27231APC. Cells were incubated in an antibody dilution of 0.5 ug/mL for 20 minutes at room temperature. A co-stain was performed with NBP2-26646. Image using the Allophycocyanin form of this antibody.

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Summary
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Description

This antibody detects a monomorphic general framework determinant of HLA-DR Class II antigen. It does not cross react with HLA-DP and HLA-DQ. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense cytoplasmic staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.