HP1a mouse antibody (mAb) (Clone 2HP-1H5)
Product Details
- Cat. No.
- 39977
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
HP1a (Heterochromatin protein 1 alpha) is a chromosomal protein that participates in both chromatin packaging and gene silencing. Three HP1 isoforms (a, b and g) occur in mammals. The chromodomain of HP1a is responsible for binding to histone H3 methylated at lysine 9, although additional factors are required to specify the HP1 targeting. The chromo shadow domain mediates interactions with a number of nuclear proteins, including SuvH39 (a Histone H3 Lysine methyltransferase), the DNA methyltransferases DNMT1 and DNMT3A or the large subunit of the chromatin assembly factor-1 (CAF-1). Dysfunction of HP1a plays a critical role in tumorigenesis, and is implicated in the invasive/metastatic phenotype of breast cancer.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse
- Clone: 2HP-1H5
- Isotype: IgG1k
Handling
- Quantity: 100 ug
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Chromatin Immunoprecipitation (ChIP)
- Immunofluorescence (IF)