HRas Antibody
Product Details
- Cat. No.
- 251442
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
GTPase HRas (HRas) binds GDP/GTP and possess intrinsic GTPase activity. HRas alternates between an inactive form bound to GDP and an active form bound to GTP. HRas is activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Defects in HRAS are the cause of Costello syndrome (COSTS), also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, postnatal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, and skin and musculoskeletal abnormalities.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human HRas.
- Isotype: Rabbit Ig
- Gene: P01112
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)