HUMAN ANTI GOLIMUMAB
Product Details
- Cat. No.
- HCA242
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Human
Human anti golimumab specificity ELISA
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Description
Human anti golimumab, clone AbD20897 is a Type 2 anti-idiotypic antibody that specifically recognizes free golimumab and the drug/tumor necrosis factor alpha (TNFα) complex. Clone AbD20897 does not inhibit the binding of golimumab to TNFα and can be used to measure the total golimumab levels in serum from patients, or for pharmacokinetic (PK) assay development.An affinity matured variant of HCA242 is available with about 7-fold affinity improvement, clone AbD25455 (HCA289).Golimumab, marketed under the brand name Simponi, is a recombinant human IgG1/kappa monoclonal antibody approved for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. This therapeutic antibody, directed against TNFα, acts by blocking the binding of TNFα to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.View a summary of all anti-golimumab antibodies
Biological Information
- Clonality: Monoclonal
- Host: Human
- Isotype: HuCAL Fab monovalent
Handling
- Quantity: 0.1 mg
- Storage: +4ºC, -20ºC if preferred
- Buffer: Phosphate buffered saline, 0.01% Thiomersal
Applications
- ELISA (ELISA)
