HUMAN ANTI GOLIMUMAB

Human Anti-Golimumab Antibody, clone AbD25451_hIgG1 is an anti-idiotypic antibody that specifically recognizes the monoclonal antibody drug golimumab. This antibody binds to both free golimumab and to golimumab bound to its target tumor necrosis factor alpha (TNFα). Clone AbD25451_hIgG1 does not inhibit the binding of golimumab to its target TNFα and can be used to measure total golimumab and biosimilar products in bioanalytical assays.Clone AbD25451_hIgG1 is an affinity-matured variant of AbD20897 (HCA242), with about 17-fold affinity improvement.A pair of anti golimumab antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure total drug. This antibody, in full immunoglobulin format, is recommended as the detection antibody paired with clone AbD25455 (HCA289) as the capture antibody.Golimumab, marketed under the brand name Simponi is a recombinant human IgG1/kappa monoclonal antibody approved for the treatment of rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. This therapeutic antibody, directed against TNFα, acts by blocking the binding of TNFα to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.View a summary of all anti-golimumab antibodies

• Clonality: Monoclonal
• Host: Human
• Isotype: IgG1

• Quantity: 0.1 mg
• Storage: +4ºC, -20ºC if preferred
• Buffer: Phosphate buffered saline, 0.01% Thiomersal

• ELISA (ELISA)