Product & ReviewsAntibodies

HUMAN ANTI PANITUMUMAB

Product Details

Cat. No.
HCA265
Type
Primary Antibody
Clonality
Monoclonal
Host
Human
Buy Now
Bio-Rad

Receive your quote directly from the manufacturer.

Description

Human anti panitumumab, clone AbD23897_hIgG1, is a paratope specific, high affinity, anti-idiotypic antibody that specifically recognizes the fully human monoclonal antibody drug panitumumab and inhibits it binding to its target, epidermal growth factor receptor (EGFR). The antibody can be used to measure the levels of panitumumab and biosimilar products in bioanalytical assays.Clone AbD23897_hIgG1 is a fully human recombinant monoclonal antibody with IgG1 isotype and is suitable as a reference standard in an anti-drug antibody (ADA) assay. Additionally the antibody can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. This antibody, in full immunoglobulin format, is recommended as the detection antibody, paired with the antibody clone AbD23894 (HCA264) in monovalent Fab format, as the capture antibody.Panitumumab (Vectibix®) is a fully human monoclonal antibody (IgG2/kappa) specific to the transmembrane protein EGFR. The drug binds to the extracellular domain of the EGFR, inhibiting the activation of the intracellular signaling cascade. It is approved by the FDA and EMA for the treatment of EGFR-expressing metastatic colorectal cancer.View a summary of all anti panitumumab antibodies

Biological Information

  • Clonality: Monoclonal
  • Host: Human
  • Isotype: IgG1

Handling

  • Quantity: 0.1 mg
  • Storage: +4ºC, -20ºC if preferred
  • Buffer: Phosphate buffered saline, 0.01% Thiomersal

Applications

  • ELISA (ELISA)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links